COMPOSITIONS :
Cotrimoxazole Forte Caplet, each caplet contains : Sulfamethoxazole 800 mg and Trimethoprim 160 mg.
DESCRIPTIONS :
Cotrimoxazole with active ingredient Sulfamethoxazole and Trimethoprimare available in tablets 480 mg, caplets 960 mg and suspension 240 mg/5 ml. Cotrimoxazole tablet contains Sulfamethoxazole 400 mg and Trimethoprim 80 mg. Cotrimoxazole Forte caplet contains Sulfamethoxazole 800 mg and Trimethoprim 160 mg. Cotrimoxazole suspension contains Sulfamethoxazole 200 mg/5 ml and Trimethoprim 40 mg/5 ml.
INDICATIONS :
– Urinary tract infections such as pyelonephritis, pyelitis, acute and chronic prostates caused by sensitive microorganisms like : E. coli, Klebsiella, Enterobacter and Proteus mirabilis.
– Gastrointestinal tract infections, especially caused by Salmonella and Shigella, such as, typhoid fever, paratyphoid and bacillary dysentery.
– Respiratory tract infections such as acute bronchitis and acute sinusitis caused by H. influenzae and S. pneumoniae.
– ENT infections such as : Acute otitis media and acute sinusitis caused by H. influenzae and S. pneumoniae.
DOSAGE AND ADMINISTRATIONS :
Cotrimoxazole Tablet and Cotrimoxazole Forte Caplet
Adults and children over 12 years :
| Dosage | Cotrimoxazole | Cotrimoxazole Forte |
| Usual dosage (for 10 – 14 days) | 2 x 2 tablets daily | 2 x 1 caplets daily |
| For long therapy dosage (> 14 days) | 2 x 1 tablets daily | 2 x ½ caplets daily |
| For severe infections | 2 x 3 tablets daily | 2 x 1½ caplets daily |
| Uncomplicated gonorrhoea (for 2 days) | 2 x 4 tablets daily | 2 x 2 caplets daily |
Taken this drug in the morning or evening after meal and drink a large amount of water.
CONTRAINDICATIONS :
– Patients which known sensitive to sulfonamides or Trimethoprim.
– Babies under 2 months.
– Megaloblastic anemia patients caused by folic deficiencies.
– Pregnant and breastfeeding woman, because sulfonamides can pass through placenta and excreted in breast milk and caused kernicterus.
WARNINGS AND PRECAUTIONS :
– When using this drug, drink a lot of water to avoid crystalluria.
– Patients with renal impairment, the dosage should be reduced. The administration should be with long interval to avoid drug cumulative effect in blood.
– Routine blood checked, recommended when this drug used in a long period, because it may caused blood dyscrasia.
– Not recommended for pharyngitis caused by β-hemolytic Streptococcus group A.
– Stop Cotrimoxazole usage if skin rash or other serious side effect appeared when using this drug.
DRUG INTERACTIONS :
- Cotrimoxazole can increased the effect of anticoagulant agents and extend the half lives of Phenytoin also can influences the dosage of hypoglycemic agents.
- Reported that Cotrimoxazole can caused megaloblastic anemia if it’s administered concomitant with drugs which can inhibit folic production e.g. Pyrimethamine.
- Concomitant therapy with diuretic especially thiazide can increase the incidence of thrombocytopenia.
ADVERSE REACTIONS :
– Nausea, vomiting, skin rash.
– Leucopenia, trombositopenia, agranulocytosis, aplastic anemia, blood dyscrasia.
– On long term administration caused megaloblastic anemia, even rarely reported but this syndrome can be tolerated with folic acid therapy.
– Even rarely reported can caused fatal hypersensitivity reaction on skin or blood like Stevens Johnson Syndrome, epidermal toxic, fulminant necrosis, hepatic necrosis and other blood dyscrasia.
PRESENTATIONS :
Cotrimoxazole Forte Caplet Box, 10 strips @ 10 caplets Reg. No. GKL1002342404A1
STORAGE :
STORE BELOW 30ºC, PROTECT FROM LIGHT
ON MEDICAL PRESCRIPTION ONLY
Manufactured by :
BERNOFARM
Sidoarjo – Indonesia
